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|, ELAV1, HUR, Hua, MelG, ELAV like RNA binding protein 1|
The protein encoded by this gene is a member of the ELAVL protein family. This encoded protein contains 3 RNA-binding domains and binds cis-acting AU-rich elements. One of its best-known functions is to stabilize mRNAs in order to regulate gene expression.
- GRCh38: Ensembl release 89: ENSG00000066044 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000040028 - Ensembl, May 2017
- "Human PubMed Reference:".
- "Mouse PubMed Reference:".
- Ma WJ, Cheng S, Campbell C, Wright A, Furneaux H (Jun 1996). "Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein". J Biol Chem. 271 (14): 8144–8151. doi:10.1074/jbc.271.14.8144. PMID 8626503.
- Ma WJ, Furneaux H (Feb 1997). "Localization of the human HuR gene to chromosome 19p13.2". Hum Genet. 99 (1): 32–33. doi:10.1007/s004390050305. PMID 9003489.
- "Entrez Gene: ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)".
This further reading section may contain inappropriate or excessive suggestions. Please ensure that only a reasonable number of balanced, topical, reliable, and notable further reading suggestions are given. Consider utilising appropriate texts as inline sources or creating a separate bibliography article. (March 2017)
- Nabors LB, Suswam E, Huang Y, Yang X, Johnson MJ, King PH (2003). "Tumor necrosis factor alpha induces angiogenic factor up-regulation in malignant glioma cells: a role for RNA stabilization and HuR". Cancer Res. 63 (14): 4181–7. PMID 12874024.
- Abdelmohsen K, Lal A, Kim HH, Gorospe M (2007). "Posttranscriptional orchestration of an anti-apoptotic program by HuR". Cell Cycle. 6 (11): 1288–92. doi:10.4161/cc.6.11.4299. PMID 17534146.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Sakai K, Kitagawa Y, Hirose G (1999). "Analysis of the RNA recognition motifs of human neuronal ELAV-like proteins in binding to a cytokine mRNA". Biochem. Biophys. Res. Commun. 256 (2): 263–268. doi:10.1006/bbrc.1999.0282. PMID 10079173.
- Wang W, Furneaux H, Cheng H, et al. (2000). "HuR regulates p21 mRNA stabilization by UV light". Mol. Cell. Biol. 20 (3): 760–769. doi:10.1128/MCB.20.3.760-769.2000. PMC 85192. PMID 10629032.
- Blaxall BC, Pellett AC, Wu SC, et al. (2000). "Purification and characterization of beta-adrenergic receptor mRNA-binding proteins". J. Biol. Chem. 275 (6): 4290–4297. doi:10.1074/jbc.275.6.4290. PMID 10660597.
- Park S, Myszka DG, Yu M, et al. (2000). "HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA". Mol. Cell. Biol. 20 (13): 4765–4772. doi:10.1128/MCB.20.13.4765-4772.2000. PMC 85909. PMID 10848602.
- Spångberg K, Wiklund L, Schwartz S (2000). "HuR, a protein implicated in oncogene and growth factor mRNA decay, binds to the 3' ends of hepatitis C virus RNA of both polarities". Virology. 274 (2): 378–390. doi:10.1006/viro.2000.0461. PMID 10964780.
- Brennan CM, Gallouzi IE, Steitz JA (2000). "Protein ligands to HuR modulate its interaction with target mRNAs in vivo". J. Cell Biol. 151 (1): 1–14. doi:10.1083/jcb.151.1.1. PMC 2189805. PMID 11018049.
- Gallouzi IE, Steitz JA (2001). "Delineation of mRNA export pathways by the use of cell-permeable peptides". Science. 294 (5548): 1895–1901. doi:10.1126/science.1064693. PMID 11729309.
- Goldberg-Cohen I, Furneauxb H, Levy AP (2002). "A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR". J. Biol. Chem. 277 (16): 13635–13640. doi:10.1074/jbc.M108703200. PMID 11834731.
- Wang W, Fan J, Yang X, et al. (2002). "AMP-activated kinase regulates cytoplasmic HuR". Mol. Cell. Biol. 22 (10): 3425–3436. doi:10.1128/MCB.22.10.3425-3436.2002. PMC 133799. PMID 11971974.
- Yeap BB, Voon DC, Vivian JP, et al. (2002). "Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3'-untranslated region of the androgen receptor messenger RNA". J. Biol. Chem. 277 (30): 27183–27192. doi:10.1074/jbc.M202883200. PMID 12011088.
- Li H, Park S, Kilburn B, et al. (2003). "Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase". J. Biol. Chem. 277 (47): 44623–44630. doi:10.1074/jbc.M206187200. PMID 12237300.
- Chen CY, Xu N, Shyu AB (2002). "Highly selective actions of HuR in antagonizing AU-rich element-mediated mRNA destabilization". Mol. Cell. Biol. 22 (20): 7268–7278. doi:10.1128/MCB.22.20.7268-7278.2002. PMC 139819. PMID 12242302.
- Giles KM, Daly JM, Beveridge DJ, et al. (2003). "The 3'-untranslated region of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein". J. Biol. Chem. 278 (5): 2937–2946. doi:10.1074/jbc.M208439200. PMID 12431987.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Wang W, Yang X, López de Silanes I, et al. (2003). "Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function". J. Biol. Chem. 278 (29): 27016–27023. doi:10.1074/jbc.M300318200. PMID 12730239.
|This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.|
You can either download the motif alignment or view it directly in your browser window. More...
You can download (or view in your browser) a text representation of a Rfam alignment in various formats:
- Gapped FASTA
- Ungapped FASTA
You can view or download motif alignments in several formats. Check either the "download" button, to save the formatted alignment, or "view", to see it in your browser window, and click "Generate".
There are 23 Rfam families which match this motif.
This section shows the families which have been annotated with this motif. Users should be aware that the motifs are structural constructs and do not necessarily conform to taxonomic boundaries in the way that Rfam families do. More...
To annotate the family with a motif model, the seed sequence was first filtered using a 0.9 fraction identity cut-off. The filtered seed was then scanned using Infernal cmscan (v1.1) with a concatenated CM file containing each of the motifs. Significance of hits between a seed sequence and the CM was based on a gathering threshold that was individually set for each motif. Only motifs where more than two and at least 10% of seed sequences scored higher than the gathering threshold were included for the next stage of processing. These subsets of motifs were then rescanned against the entire (non-filtered) seed to generate matches.
Number of Hits: the number of sequences in the family seed that score above the gathering threshold from motif.
Fraction of Hits: the fraction of sequences in the family seed that score above the gathering threshold from motif.
Sum of Bits: the sum of the bit scores of matches between the motif and the family seed sequence.
Image: plot illustrating where on the consensus secondary structure matches occur between seed sequences and the motif model.
|Original order||Family Accession||Family Description||Number of Hits||Fraction of Hits||Sum of Bits||Image|
|3||RF00025||Ciliate telomerase RNA||2||0.100||27.4|
|3||RF00028||Group I catalytic intron||3||0.250||38.9|
|3||RF00096||U8 small nucleolar RNA||8||0.145||103.1|
|3||RF00443||Small nucleolar RNA SNORA27||10||0.417||132.0|
|3||RF00488||Yeast U1 spliceosomal RNA||3||0.600||36.9|
|3||RF00563||Small nucleolar RNA SNORA53||14||0.500||173.6|
|3||RF00630||Pseudomonas sRNA P26||6||0.222||72.4|
|3||RF01249||Small nucleolar RNA snR190||2||0.200||26.0|
|3||RF01263||Small nucleolar RNA snR191||2||0.182||27.4|
|3||RF01265||Small nucleolar RNA snR42||2||0.400||27.4|
|3||RF01272||Small nucleolar RNA snR86||2||0.400||28.0|
|3||RF01583||small nucleolar RNA snoR01||2||0.667||25.6|
|3||RF01590||small nucleolar RNA snoR14||2||0.500||26.5|
|3||RF01794||sok antitoxin (CssrC)||22||0.242||307.3|
|3||RF01848||ACEA small nucleolar RNA U3||6||0.214||73.9|
|3||RF01960||Eukaryotic small subunit ribosomal RNA||11||0.121||158.5|
|3||RF02076||Gammaproteobacterial sRNA STnc100||2||0.083||25.0|
|3||RF02452||Bacillus sRNA ncr1575||4||0.138||49.4|
|3||RF02543||Eukaryotic large subunit ribosomal RNA||27||0.307||520.5|
|3||RF02834||Vibrio RNA VqmR||3||0.750||37.6|
|3||RF02858||Actinobacillus sRNA 08||2||0.667||27.5|
This section shows the database cross-references that we have for this Rfam motif.
López de Silanes I, Zhan M, Lal A, Yang X, Gorospe M Proc Natl Acad Sci U S A. 2004;101:2987-92. Identification of a target RNA motif for RNA-binding protein HuR. PUBMED:14981256
Dassi E, Zuccotti P, Leo S, Provenzani A, Assfalg M, D'Onofrio M, Riva P, Quattrone A Nucleic Acids Res. 2013 Hyper conserved elements in vertebrate mRNA 3'-UTRs reveal a translational network of RNA-binding proteins controlled by HuR. PUBMED:23376935
External database links
|External sites:|| 1: http://www.rna.icmb.utexas.edu/SIM/4B/UAA_GAN/
Curation and motif details
This section shows the detailed information about the Rfam motif. We're happy to receive updated or improved alignments for new or existing families. Submit your new alignment and we'll take a look.
|Seed source||Published; PMID:14981256|
|Type||Specific Recognition Motif|
cmbuild -F CM SEED
cmcalibrate --mpi --seed 1 CM
|Covariance model||Download the Infernal CM for the motif here|