Rfam 14.3 (September 2020,
3446 families)
The Rfam database is a collection of RNA families, each represented by multiple
sequence alignments, consensus secondary structures and covariance
models (CMs).
More...
The families in Rfam break down into three broad functional
classes: non-coding RNA genes, structured cis-regulatory
elements and self-splicing RNAs. Typically these functional
RNAs often have a conserved secondary structure which may be
better preserved than the RNA sequence. The CMs used to
describe each family are a slightly more complicated relative
of the profile hidden Markov models (HMMs) used by Pfam. CMs
can simultaneously model RNA sequence and the structure in an
elegant and accurate fashion.
Rfam families are frequently built from external sources, we ask
that if you find a particular family useful for your work that
you cite both Rfam and the primary source of our data.
If you see anything wrong with any of our alignments or
structures or there is a family that you know of missing from
Rfam please
contact us
with a suggested correction. If you see anything incorrect or omitted
from the Wikipedia
entries we display and link to then be brave and edit the entry; you
might also consider joining the
WikiProject RNA.
- QUICK LINKS
- SEQUENCE SEARCH
- VIEW AN RFAM FAMILY
- VIEW AN RFAM CLAN
- KEYWORD SEARCH
- TAXONOMY SEARCH
- JUMP TO
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You can find data in Rfam in various ways...
- Analyze your RNA sequence for Rfam matches
- View Rfam family annotation and alignments
- View Rfam clan details
- Query Rfam by keywords
- Fetch families or sequences by NCBI taxonomy
-
- Or view the help pages for
more information
Analyze your RNA sequence for Rfam matches
We developed a new sequence similarity search interface
that annotates query sequences with Rfam families and displays
related sequences from RNAcentral.
Go to new sequence search
View Rfam family annotation and alignments
Enter a family identifier or accession to see all data for that family.
View Rfam clan and alignments
Enter a family identifier or accession to see all data for that family.
View domain organisation of a RNA sequence
Enter a sequence identifier or accession.
Find the domains on a PDB structure
Enter the PDB identifier for the structure in the RNA DataBank.
Query Rfam by keyword
Search for keywords in text data in the Rfam database.
Go
Example
You can also use the
keyword search box at the top of every page.
This option will be removed soon - try new search instead
Query Rfam by taxonomy
Search for families or sequences from NCBI taxonomic classes in the Rfam database.
Recent Rfam blog posts
Citing Rfam
If you find Rfam useful, please consider
citing the references
that describe this work:
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